Proteins : Analysis and Design,9780120587858

Proteins : Analysis and Design

by
ISBN13: 9780120587858
ISBN10: 0120587858
Format: Hardcover
Pub. Date: 1998-08-01
Publisher(s): Academic Pr
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Summary

Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function.

Table of Contents

Dedication v(4)
Contributors ix(2)
Preface xi
Introduction 1(3)
Ruth Hogue Angeletti
Chapter 1 Current Problems and Technical Solutions in Protein Biochemistry
4(117)
Ruedi Aebersold
Scott D. Patterson
I. Introduction
4(2)
II. Early Events in Signaling by Interferons: From Membrane Receptor to Induced Genes
6(2)
III. Detection of Systems Components
8(9)
IV. Identification of Components of Complex Systems
17(33)
V. Analysis of Regulatory Modifications of Components of Complex Systems
50(26)
VI. Analysis of Protein: Ligand Complexes
76(17)
VII. Conclusion
93(1)
References
94(27)
Chapter 2 Posttranslational Modifications
121(87)
Radha Gudepu Krishna
Finn Wold
I. Introduction
121(4)
II. Types of Posttranslational Derivatives
125(34)
III. Types of Posttranslational Reactions: How Modifications Are Made
159(16)
IV. Biological Functions of Posttranslational Modifications: Why Modifications Are Made
175(17)
References
192(16)
Chapter 3 Design and Use of Synthetic Peptides as Biological Models
208(51)
Janelle L. Lauer
Gregg B. Fields
I. Peptides as Structural Models of Proteins
208(11)
II. Cell/Peptide Interactions
219(9)
III. Protein/Peptide Interactions
228(8)
IV. Peptides and Modulation of T-Cell Behavior
236(4)
V. Enzyme/Peptide Interactions: Peptides as Enzyme Substrates
240(3)
VI. Summary
243(1)
References
243(16)
Chapter 4 Site-Directed Mutagenesis and Protein Engineering
259(54)
Gary S. Coombs
David R. Corey
I. Introduction
259(1)
II. Why Alter Proteins?
260(1)
III. Techniques for Oligonucleotide-Directed Mutagenesis
261(11)
IV. Strategies for Engineering Proteins
272(19)
V. Case Studies: Introduction of Function by Site-Directed Mutagenesis
291(11)
VI. Conclusion
302(1)
References
303(10)
Chapter 5 De Novo Design of Protein Structure and Function
313(42)
Michael W. Klemba
Mary Munson
Lynne Regan
I. Introduction and Overview
313(1)
II. De Novo Design of Structure
314(5)
III. Characterizing the Design
319(1)
IV. Selected Examples of Designed Proteins
320(11)
V. De Novo Design of Function
331(13)
VI. Design of Catalytic Proteins
344(4)
VII. Summary and Future Directions
348(1)
References
348(7)
Index 355

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