| Foreword |
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xi | |
| Preface |
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xiii | |
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Importance of Biomembrane Transport |
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1 | (2) |
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Solute and Solvent Fluxes Are Determined by Barriers and Propelling Forces |
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3 | (4) |
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Biomembrane Transport in Context |
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7 | (3) |
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10 | (3) |
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Biomembrane Composition, Structure, and Turnover |
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13 | (1) |
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Is the Fluid Mosaic Model of Membrane Structure Still Adequate? |
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13 | (16) |
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Some Components of the Biomembrane Can Be Reconstituted |
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29 | (1) |
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How Are Biomembrane Composition and Structure Regulated? |
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30 | (8) |
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38 | (1) |
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Themodynamics and Transport |
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39 | (1) |
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Similar Mathematical Expressions Serve for the Free Energy Change in a Chemical Reaction and in the Migration of a Solute or Solvent |
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39 | (4) |
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Changes in Enthalpy and Entropy May Contribute Differently to the Free Energy Changes Associated with a Biochemical Reaction and Migration of a Solute |
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43 | (1) |
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The Total Chemical Potential Change for a Transport Process Also May Have an Electrical Component |
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44 | (3) |
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The Gibbs--Donnan Effect Also Generates Osmotic Pressure |
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47 | (2) |
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Chemical Reactions Drive Primary Active Transport |
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49 | (6) |
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Reversal of Transport May Drive Chemical Reactions |
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55 | (1) |
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How Do Fluctuations in the Local Hydrogen Ion Potential Facilitate Formation of Phosphoric Acid Anhydride Bonds by the Mitochondrial F0F1-1 ATP Synthase? |
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56 | (1) |
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Conversion of Solute Total Chemical Potential Gradients to Gradients of Other Solutes during Co- and Countertransport |
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57 | (4) |
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Dissipation of Solute Gradients through Mediated Transport Processes May Also Perform Work |
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61 | (2) |
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Application of Thermodynamic Principles to the Solution of Practical Transport Problems |
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63 | (1) |
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63 | (2) |
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65 | (1) |
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66 | (4) |
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How Do Measurements of both the Diffusional and the Osmotic Permeability Coefficient for Water Inform Us about the Mechanism of Water Transport across a Plasma Membrane? |
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70 | (3) |
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Do Lipophilic Substances Migrate across Biomembrane Phospholipid Bilayers by Simple Diffusion? |
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73 | (1) |
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Lipid-Soluble Substances Are Used to Attempt to Measure the Width of Unstirred Water Layers on Either Side of Biomembranes |
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74 | (2) |
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Do Such Determinations of the Apparent Widths of Unstirred Water Layers Reflect the Intended Physical Phenomenon or Our Ignorance of How Lipid-Soluble Substances Cross Biomembranes? |
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76 | (3) |
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Protein versus Lipid-Mediated Mechanisms of Fatty Acid Migration across Biomembranes |
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79 | (2) |
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Protein-Mediated Biomembrane Transport Is Probably Always Substrate Saturable |
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81 | (2) |
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Kinetics of Saturable Transport |
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83 | (15) |
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Identification and Minimization or Deduction of Processes That May Obscure a Transport Process of Interest |
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98 | (18) |
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Kinetic Differences among Substrate-Saturable Transport Processes That Form, Propagate, or Dissipate Solute Gradients |
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116 | (8) |
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124 | (2) |
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126 | (7) |
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Structure and Function of Transport Proteins That Form Solute Gradients |
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133 | (2) |
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135 | (17) |
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F°F1-ATP Synthases (F-Type ATPases) |
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152 | (14) |
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166 | (3) |
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Transport Proteins That Propagate Solute Gradients |
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Introduction to Symporters and Antiporters |
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169 | (1) |
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Both Erythroid and Nonerythroid Tissues Express Anion Exchangers |
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170 | (38) |
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ASC and Excitatory (Anionic) Amino Acid Transporters Comprise One of Two Known Families of Mammalian Na+/Amino Acid Symporters |
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208 | (25) |
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Both AE and EAAT/ASC Proteins Have Additional Functions |
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233 | (4) |
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237 | (2) |
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Channel Proteins Usually Dissipate Solute Gradients |
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239 | (1) |
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Structure, Function, and Evolution of Channel Proteins |
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240 | (14) |
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Kinetics of Transport via K+ and Other Channels |
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254 | (8) |
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262 | (3) |
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A Proposed System for the Classification of Transmembrane Transport Proteins in Living Organisms |
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265 | (1) |
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Work of the Enzyme Commission as a Basis for the Systematic Classification of Transport Proteins |
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265 | (1) |
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Phylogeny as a Basis for Protein Classification: Criteria for Family Assignment |
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266 | (1) |
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Proposed Transport Protein Classification System |
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267 | (5) |
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Representative Examples of Classified Families |
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272 | (1) |
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Cross-Classification of Transport Proteins |
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272 | (3) |
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The Two Largest Superfamilies of Transporters: The MF and ABC Superfamilies |
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275 | (1) |
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Macromolecular Transport Proteins in Bacteria |
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275 | (1) |
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Conclusions and Perspectives |
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276 | (1) |
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Regulation of Plasma Membrane Transport |
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277 | (1) |
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Regulation of Transport by Changes in Driving Force: The Role of Plasma Membrane Potential |
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277 | (1) |
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Regulation of the Activity of Existing Transporters through Modifications of Transporter Molecules |
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278 | (6) |
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Regulation of Transport by Changes in the Repertoire of Transport Proteins in the Plasma Membrane |
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284 | (3) |
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Coordinated Regulation of Transport Systems |
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287 | (1) |
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Derangements in Transport Regulation |
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287 | (6) |
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293 | (2) |
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Biomembrane Transport and Interorgan Nutrient Flows: The Amino Acids |
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295 | (1) |
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Interorgan Amino Acid Nutrition: General Principles and Key Issues |
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295 | (13) |
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Control of Interorgan Amino Acid Metabolism: Metabolic Control Theory and Safety Factors |
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308 | (3) |
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Physiologically Important Flows of Amino Acids and Related Compounds |
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311 | (8) |
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Amino Acid Nutrition under Special Circumstances |
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319 | (6) |
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325 | (2) |
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Selected Techniques in Membrane Transport |
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327 | (1) |
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Purification and Reconstitution of Transport Proteins |
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327 | (1) |
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Methods for Isolating cDNAs Coding for Transport Proteins |
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328 | (1) |
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Heterologous Expression Systems for Transport Proteins |
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329 | (3) |
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Voltage-Clamp Techniques in Xenopus Oocytes |
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332 | (6) |
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Probing Transport with Ion-Selective Microelectrodes |
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338 | (1) |
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Optical Methods for Measuring Membrane Transport |
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339 | (1) |
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Structure--Function Studies of Transport Proteins |
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339 | (2) |
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Genetic Approaches to Understanding Transporter Function |
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341 | (1) |
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Summary of Preparations Used to Study Native Membrane Transport |
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341 | (2) |
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| Epilogue |
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343 | (2) |
| References |
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345 | (42) |
| Index |
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387 | |
Other versions by this Author
